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Hexarelin

Hexarelin is a synthetic hexapeptide amide, His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, structurally the growth-hormone-secretagogue reference peptide GHRP-6 bearing a single 2-methyl substitution on the position-2 D-tryptophan.

CAS 140703-51-1Mol. weight 887.04 g/molResearch Use Only · reference
2D structure of Hexarelin (PubChem CID 6918297)
2D structure via PubChem (CID 6918297). Public domain.
Computed 3D conformation (illustrative) · from the verified structure.

Identity & structure

H
D-2-Me-Trp
A
W
D-Phe
K
–NH₂

Primary sequence · 6 residues · C-terminal amide · Hexapeptide amide; the 2-methyl group on the position-2 D-tryptophan is the single substitution distinguishing hexarelin from GHRP-6.

Hexarelin — identity and specification
Identity
CAS140703-51-1
PubChem CID6918297
FDA UNII09QF37C617
Also known asExamorelin, EP-23905, MF-6003, Hexarelin peptide
Research classSecretagogue & Regulatory
Structure
Molecular formulaC47H58N12O6
InChIKeyRVWNMGKSNGWLOL-GIIHNPQRSA-N
SequenceHis-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2
Length6 residues
Analytical
Average molecular weight887.04 g/mol
Monoisotopic mass886.4602 Da (computed)

A C-terminally amidated hexapeptide carrying two D-configured residues (D-2-methyl-Trp at position 2 and D-Phe at position 5). The 2-methyl group on the position-2 D-tryptophan is the single substitution that distinguishes hexarelin from GHRP-6, accounting for the one-CH2 difference between C47H58N12O6 and C46H56N12O6.

Reference context

Hexarelin is a synthetic hexapeptide amide, His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, structurally the growth-hormone-secretagogue reference peptide GHRP-6 bearing a single 2-methyl substitution on the position-2 D-tryptophan. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C47H58N12O6 and the values computed from it. No biological activity, mechanism, or use is described or implied.

Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.

How Hexarelin is characterized

Identity rests on the molecular formula and mass. Electrospray mass spectrometry (ESI-MS) measures the mass-to-charge ratio of the intact molecule; the average and monoisotopic masses are computed from the verified formula and cross-check the composition. The residue sequence and the modifications noted above define the structure.

CompositionMolecular formula · 6-residue peptide
MassAverage & monoisotopic · ESI-MS
IdentityCAS · PubChem CID · UNII · InChIKey
Computed mass & m/z →How an HPLC trace is read →

Frequently asked questions

What is Hexarelin?
Hexarelin is a synthetic hexapeptide amide, His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2, structurally the growth-hormone-secretagogue reference peptide GHRP-6 bearing a single 2-methyl substitution on the position-2 D-tryptophan. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C47H58N12O6 and the values computed from it. No biological activity, mechanism, or use is described or implied.
What is the amino-acid sequence of Hexarelin?
Hexarelin has the sequence His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2. A C-terminally amidated hexapeptide carrying two D-configured residues (D-2-methyl-Trp at position 2 and D-Phe at position 5). The 2-methyl group on the position-2 D-tryptophan is the single substitution that distinguishes hexarelin from GHRP-6, accounting for the one-CH2 difference between C47H58N12O6 and C46H56N12O6.
What is the molecular formula of Hexarelin?
Hexarelin has the molecular formula C47H58N12O6, giving an average molecular weight of 887.04 g/mol and a computed monoisotopic mass of 886.4602 Da.
What are the key chemical identifiers for Hexarelin?
The CAS Registry Number for Hexarelin is 140703-51-1. Its PubChem CID is 6918297, its FDA UNII is 09QF37C617, and its InChIKey is RVWNMGKSNGWLOL-GIIHNPQRSA-N.
Is Hexarelin a peptide?
Yes. Hexarelin is a peptide — a chain of amino-acid residues joined by peptide bonds, 6 residues in length. Its identity is defined by that sequence and its molecular mass.
How is Hexarelin stored and reconstituted?
As a research material, Hexarelin is typically handled as a lyophilized (freeze-dried) powder. It is kept desiccated and cold — commonly 2–8 °C for short periods and −20 °C for longer storage — and reconstituted in sterile or bacteriostatic water. This is storage and handling information only, not a use protocol.
Does Lineará sell Hexarelin?
No. Hexarelin is listed here only as an analytical reference entity. It is not part of the Lineará formulary, has no price or certificate of analysis, and is not offered for sale.
Is Hexarelin approved for human use?
No. Hexarelin is presented strictly as characterization reference data. It is not a drug, is not approved for any human or veterinary use, and must not be administered to humans or animals.

Data, tools & related references

Peptide fundamentals
What are peptides? — peptide bonds, structure & chemistry
→
Peptide chemistry glossary — defined terms
→
Analytical data & tools
Hexarelin molecular weight, m/z & pI
→
Peptide mass & m/z calculator
→
Open compound dataset (CSV · JSON)
→
Research class
Secretagogue & Regulatory — research class
→
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→
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→
Glutathione
→
CJC-1295
→
5-Amino-1MQ
→
NAD+
→
GHRP-2
→
GHRP-6
→
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→
SLU-PP-332
→
Adipotide
→
IGF-1 LR3
→
Sermorelin
→
Amlexanox
→
B7-33
→
Pancragen
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Gonadorelin
→
AICAR
→

References

  1. PubChem — compound identity, structure & computed properties (CID 6918297). PubChem →
  2. CAS Registry Number 140703-51-1.
  3. FDA Global Substance Registration System — UNII 09QF37C617.

Research professionals only

Reference data

This monograph is characterization reference data. Lineará does not sell, stock, or certify Hexarelin.

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