B7-33

B7-33 is a 27-residue single-chain analogue of the B-chain of human gene-2 relaxin (H2 relaxin, RLN2), engineered as a functionally selective relaxin-family peptide receptor (RXFP1) agonist, with a C-terminal primary amide and the sequence VIKLSGRELVRAQIAISGMSTWSKRSL. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C131H229N41O36S and the values computed from it. "relaxin-family peptide receptor (RXFP1) agonist" is a structural-family descriptor; no biological activity, mechanism, or use is described or implied.

B7-33 has the sequence VIKLSGRELVRAQIAISGMSTWSKRSL. B7-33 is a 27-residue single-chain peptide derived from the B-chain of human gene-2 relaxin (H2 relaxin, RLN2): the first six residues of the relaxin B1–33 isoform are removed (leaving B-chain positions 7–33), the two native cysteines at positions 11 and 23 are substituted with serine so that no disulfide can form, and the C-terminus is capped as a primary amide. Its single-letter sequence VIKLSGRELVRAQIAISGMSTWSKRSL carries one methionine — the lone sulfur in the molecular formula C131H229N41O36S — and no cysteine. This single linear chain distinguishes B7-33 from native relaxin and serelaxin, which are two-chain, three-disulfide, insulin-like heterodimers. Identity is reconciled against PubChem CID 162662592: molecular formula and the stereo-defined InChIKey UAGASAJLEJWQIF-GARFIVTISA-N both match a peptide built independently from the sequence (twenty-nine stereocentres, none unassigned), and the average mass computed from the sequence (about 2986.6 Da) agrees with the value reported for this species. The name denotes B-chain residues 7 through 33 — 27 residues; a “26-residue” figure that circulates elsewhere is a miscount.

B7-33 has the molecular formula C131H229N41O36S, giving an average molecular weight of 2986.58 g/mol and a computed monoisotopic mass of 2984.7070 Da.

The CAS Registry Number for B7-33 is 1818415-56-3. Its PubChem CID is 162662592 and its InChIKey is UAGASAJLEJWQIF-GARFIVTISA-N.

Yes. B7-33 is a peptide — a chain of amino-acid residues joined by peptide bonds, 27 residues in length. Its identity is defined by that sequence and its molecular mass.

As a research material, B7-33 is typically handled as a lyophilized (freeze-dried) powder. It is kept desiccated and cold — commonly 2–8 °C for short periods and −20 °C for longer storage — and reconstituted in sterile or bacteriostatic water. This is storage and handling information only, not a use protocol.

No. B7-33 is listed here only as an analytical reference entity. It is not part of the Lineará formulary, has no price or certificate of analysis, and is not offered for sale.

No. B7-33 is presented strictly as characterization reference data. It is not a drug, is not approved for any human or veterinary use, and must not be administered to humans or animals.