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Secretagogue & RegulatoryOpen access · public

Adipotide

Adipotide is a synthetic chimeric peptidomimetic that joins a disulfide-cyclized prohibitin-homing nonapeptide, CKGGRAKDC, through a Gly-Gly linker to a pro-apoptotic domain of D-amino acids written D(KLAKLAK)2, for 25 residues in total.

CAS 859216-15-2Mol. weight 2555.21 g/molResearch Use Only · reference
2D structure of Adipotide (computed from the verified SMILES)
2D depiction computed with RDKit from the verified SMILES.
Computed 3D conformation (illustrative) · from the verified structure.

Identity & structure

C
K
G
G
R
A
K
D
C
G
G
D-K
D-L
D-A
D-K
D-L
D-A
D-K
D-K
D-L
D-A
D-K
D-L
D-A
D-K

Primary sequence · 25 residues · disulfide bridge Cys1–Cys9 · 25-residue chimeric peptide: a disulfide-cyclized prohibitin-homing loop CKGGRAKDC (Cys1-Cys9 bridge), a Gly-Gly linker, and a pro-apoptotic domain (KLAKLAK)2 built entirely of D-amino acids. The leading "D" in D(KLAKLAK)2 is a D-enantiomer prefix, not an aspartate. Free-acid C-terminus; the disulfide-cyclized form is canonical (PubChem CID 163360068 is the reduced open-thiol form)..

Adipotide — identity and specification
Identity
CAS859216-15-2
PubChem CID163360068
Also known asFTPP, Prohibitin-targeting peptide 1, Prohibitin-TP01, Adipotide peptide
Research classSecretagogue & Regulatory
Structure
Molecular formulaC111H204N36O28S2
SequenceCKGGRAKDC-GG-D(KLAKLAK)2
Length25 residues
Analytical
Average molecular weight2555.21 g/mol
Monoisotopic mass2553.5087 Da (computed)

Adipotide is a two-part molecule: a nonapeptide homing loop, CKGGRAKDC, closed by a disulfide bond between its two cysteines, joined through a Gly-Gly linker to a pro-apoptotic domain written D(KLAKLAK)2 — two tandem KLAKLAK repeats built entirely from D-amino acids. The leading "D" on that domain is a D-enantiomer prefix, not an aspartate residue. The canonical form shown here is the disulfide-cyclized peptide, molecular formula C111H204N36O28S2 (average mass 2555.21 g/mol, free-acid C-terminus). PubChem CID 163360068 deposits the reduced, open-thiol form of the same 25-residue sequence, C111H206N36O28S2 — two hydrogens heavier — which computes exactly from the sequence and confirms the composition; the cyclized form removes those two hydrogens on forming the S–S bond. No machine-verified InChIKey is published: for a large multi-part peptide whose canonical oxidation state differs from the deposited record, a single small-molecule key would misstate the entity, so it is represented by its verified sequence and formula instead.

Reference context

Adipotide is a synthetic chimeric peptidomimetic that joins a disulfide-cyclized prohibitin-homing nonapeptide, CKGGRAKDC, through a Gly-Gly linker to a pro-apoptotic domain of D-amino acids written D(KLAKLAK)2, for 25 residues in total. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C111H204N36O28S2 and the values computed from it. No biological activity, mechanism, or use is described or implied.

Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.

How Adipotide is characterized

Identity rests on the molecular formula and mass. Electrospray mass spectrometry (ESI-MS) measures the mass-to-charge ratio of the intact molecule; the average and monoisotopic masses are computed from the verified formula and cross-check the composition. The residue sequence and the modifications noted above define the structure.

CompositionMolecular formula · 25-residue peptide
MassAverage & monoisotopic · ESI-MS
IdentityCAS · PubChem CID

Frequently asked questions

What is Adipotide?
Adipotide is a synthetic chimeric peptidomimetic that joins a disulfide-cyclized prohibitin-homing nonapeptide, CKGGRAKDC, through a Gly-Gly linker to a pro-apoptotic domain of D-amino acids written D(KLAKLAK)2, for 25 residues in total. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C111H204N36O28S2 and the values computed from it. No biological activity, mechanism, or use is described or implied.
What is the amino-acid sequence of Adipotide?
Adipotide has the sequence CKGGRAKDC-GG-D(KLAKLAK)2. Adipotide is a two-part molecule: a nonapeptide homing loop, CKGGRAKDC, closed by a disulfide bond between its two cysteines, joined through a Gly-Gly linker to a pro-apoptotic domain written D(KLAKLAK)2 — two tandem KLAKLAK repeats built entirely from D-amino acids. The leading "D" on that domain is a D-enantiomer prefix, not an aspartate residue. The canonical form shown here is the disulfide-cyclized peptide, molecular formula C111H204N36O28S2 (average mass 2555.21 g/mol, free-acid C-terminus). PubChem CID 163360068 deposits the reduced, open-thiol form of the same 25-residue sequence, C111H206N36O28S2 — two hydrogens heavier — which computes exactly from the sequence and confirms the composition; the cyclized form removes those two hydrogens on forming the S–S bond. No machine-verified InChIKey is published: for a large multi-part peptide whose canonical oxidation state differs from the deposited record, a single small-molecule key would misstate the entity, so it is represented by its verified sequence and formula instead.
What is the molecular formula of Adipotide?
Adipotide has the molecular formula C111H204N36O28S2, giving an average molecular weight of 2555.21 g/mol and a computed monoisotopic mass of 2553.5087 Da.
What are the key chemical identifiers for Adipotide?
The CAS Registry Number for Adipotide is 859216-15-2. Its PubChem CID is 163360068.
Is Adipotide a peptide?
Yes. Adipotide is a peptide — a chain of amino-acid residues joined by peptide bonds, 25 residues in length. Its identity is defined by that sequence and its molecular mass.
How is Adipotide stored and reconstituted?
As a research material, Adipotide is typically handled as a lyophilized (freeze-dried) powder. It is kept desiccated and cold — commonly 2–8 °C for short periods and −20 °C for longer storage — and reconstituted in sterile or bacteriostatic water. This is storage and handling information only, not a use protocol.
Does Lineará sell Adipotide?
No. Adipotide is listed here only as an analytical reference entity. It is not part of the Lineará formulary, has no price or certificate of analysis, and is not offered for sale.
Is Adipotide approved for human use?
No. Adipotide is presented strictly as characterization reference data. It is not a drug, is not approved for any human or veterinary use, and must not be administered to humans or animals.

Data, tools & related references

References

  1. PubChem — compound identity, structure & computed properties (CID 163360068). PubChem →
  2. CAS Registry Number 859216-15-2.

Research professionals only

Reference data

This monograph is characterization reference data. Lineará does not sell, stock, or certify Adipotide.

áFor Research Use Only · Not for human or veterinary use · Not for diagnostic or therapeutic use