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Secretagogue & RegulatoryOpen access · public

GHRP-6

GHRP-6 is a synthetic hexapeptide amide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, first described in 1984 as [His1,Lys6]GHRP and the structural parent of the growth-hormone-secretagogue peptide family.

CAS 87616-84-0Mol. weight 873.02 g/molResearch Use Only · reference
2D structure of GHRP-6 (PubChem CID 9919153)
2D structure via PubChem (CID 9919153). Public domain.
Computed 3D conformation (illustrative) · from the verified structure.

Identity & structure

H
D-Trp
A
W
D-Phe
K
–NH₂

Primary sequence · 6 residues · C-terminal amide · Hexapeptide amide; the prototype growth-hormone-secretagogue peptide ([His1,Lys6]GHRP, Bowers et al. 1984).

GHRP-6 — identity and specification
Identity
CAS87616-84-0
PubChem CID9919153
FDA UNII4H7N4I6X6A
Also known asGrowth hormone releasing hexapeptide, SKF-110679, Hexapeptide-2, [His1,Lys6]-GHRP, GHRP 6, GHRP6, GHRP-6 peptide
Research classSecretagogue & Regulatory
Structure
Molecular formulaC46H56N12O6
InChIKeyWZHKXNSOCOQYQX-FUAFALNISA-N
SequenceHis-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Length6 residues
Analytical
Average molecular weight873.02 g/mol
Monoisotopic mass872.4446 Da (computed)

A C-terminally amidated hexapeptide with D-configured tryptophan at position 2 and D-configured phenylalanine at position 5. First described by Bowers and colleagues in 1984 as [His1,Lys6]GHRP, it is the structural parent of hexarelin, which adds a 2-methyl group to the position-2 D-tryptophan.

Reference context

GHRP-6 is a synthetic hexapeptide amide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, first described in 1984 as [His1,Lys6]GHRP and the structural parent of the growth-hormone-secretagogue peptide family. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C46H56N12O6 and the values computed from it. No biological activity, mechanism, or use is described or implied.

Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.

How GHRP-6 is characterized

Identity rests on the molecular formula and mass. Electrospray mass spectrometry (ESI-MS) measures the mass-to-charge ratio of the intact molecule; the average and monoisotopic masses are computed from the verified formula and cross-check the composition. The residue sequence and the modifications noted above define the structure.

CompositionMolecular formula · 6-residue peptide
MassAverage & monoisotopic · ESI-MS
IdentityCAS · PubChem CID · UNII · InChIKey
Computed mass & m/z →How an HPLC trace is read →

Frequently asked questions

What is GHRP-6?
GHRP-6 is a synthetic hexapeptide amide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2, first described in 1984 as [His1,Lys6]GHRP and the structural parent of the growth-hormone-secretagogue peptide family. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C46H56N12O6 and the values computed from it. No biological activity, mechanism, or use is described or implied.
What is the amino-acid sequence of GHRP-6?
GHRP-6 has the sequence His-D-Trp-Ala-Trp-D-Phe-Lys-NH2. A C-terminally amidated hexapeptide with D-configured tryptophan at position 2 and D-configured phenylalanine at position 5. First described by Bowers and colleagues in 1984 as [His1,Lys6]GHRP, it is the structural parent of hexarelin, which adds a 2-methyl group to the position-2 D-tryptophan.
What is the molecular formula of GHRP-6?
GHRP-6 has the molecular formula C46H56N12O6, giving an average molecular weight of 873.02 g/mol and a computed monoisotopic mass of 872.4446 Da.
What are the key chemical identifiers for GHRP-6?
The CAS Registry Number for GHRP-6 is 87616-84-0. Its PubChem CID is 9919153, its FDA UNII is 4H7N4I6X6A, and its InChIKey is WZHKXNSOCOQYQX-FUAFALNISA-N.
Is GHRP-6 a peptide?
Yes. GHRP-6 is a peptide — a chain of amino-acid residues joined by peptide bonds, 6 residues in length. Its identity is defined by that sequence and its molecular mass.
How is GHRP-6 stored and reconstituted?
As a research material, GHRP-6 is typically handled as a lyophilized (freeze-dried) powder. It is kept desiccated and cold — commonly 2–8 °C for short periods and −20 °C for longer storage — and reconstituted in sterile or bacteriostatic water. This is storage and handling information only, not a use protocol.
Does Lineará sell GHRP-6?
No. GHRP-6 is listed here only as an analytical reference entity. It is not part of the Lineará formulary, has no price or certificate of analysis, and is not offered for sale.
Is GHRP-6 approved for human use?
No. GHRP-6 is presented strictly as characterization reference data. It is not a drug, is not approved for any human or veterinary use, and must not be administered to humans or animals.

Data, tools & related references

Peptide fundamentals
What are peptides? — peptide bonds, structure & chemistry
→
Peptide chemistry glossary — defined terms
→
Analytical data & tools
GHRP-6 molecular weight, m/z & pI
→
Peptide mass & m/z calculator
→
Open compound dataset (CSV · JSON)
→
Compare
GHRP-2 vs GHRP-6
→
Research class
Secretagogue & Regulatory — research class
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References

  1. PubChem — compound identity, structure & computed properties (CID 9919153). PubChem →
  2. CAS Registry Number 87616-84-0.
  3. FDA Global Substance Registration System — UNII 4H7N4I6X6A.

Research professionals only

Reference data

This monograph is characterization reference data. Lineará does not sell, stock, or certify GHRP-6.

Browse Secretagogue & Regulatory researchHow to read a COA
áFor Research Use Only · Not for human or veterinary use · Not for diagnostic or therapeutic use

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