AICAR
AICAR is a synthetic small molecule - not a peptide - the purine nucleoside analog acadesine (5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside), an aminoimidazole-carboxamide base on a beta-D-ribofuranose sugar with no phosphate.
AICAR is a small molecule - a purine nucleoside analog (an aminoimidazole-carboxamide riboside) - not a peptide: it contains no amino-acid residues and no peptide bonds.
Identity & structure
| Identity | |
|---|---|
| CAS | 2627-69-2 |
| PubChem CID | 17513 |
| FDA UNII | 53IEF47846 |
| Also known as | Acadesine, AICA riboside, AICA ribonucleoside, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, N1-(beta-D-Ribofuranosyl)-5-aminoimidazole-4-carboxamide |
| Research class | Secretagogue & Regulatory |
| Structure | |
| Molecular formula | C9H14N4O5 |
| InChIKey | RTRQQBHATOEIAF-UUOKFMHZSA-N |
| Analytical | |
| Average molecular weight | 258.23 g/mol |
| Monoisotopic mass | 258.0964 Da (computed) |
AICAR (acadesine) is the ribonucleoSIDE 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside: an aminoimidazole-carboxamide base joined to a beta-D-ribofuranose sugar, formula C9H14N4O5, with no phosphate. It must be distinguished from the phosphorylated ribonucleoTIDE ZMP (the 5'-monophosphate, C9H15N4O8P, PubChem CID 65110), a different molecule; the entity supplied and characterized as "AICAR" is the unphosphorylated riboside. Identity is reconciled against PubChem CID 17513 (CAS 2627-69-2): the stereo-defined InChIKey RTRQQBHATOEIAF-UUOKFMHZSA-N, computed with RDKit from the isomeric SMILES, matches the deposited record exactly. The UNII 53IEF47846 is recorded from a single source and is flagged for confirmation at the chemist sign-off.
Reference context
AICAR is a synthetic small molecule - not a peptide - the purine nucleoside analog acadesine (5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside), an aminoimidazole-carboxamide base on a beta-D-ribofuranose sugar with no phosphate. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C9H14N4O5 and the values computed from it. No biological activity, mechanism, or use is described or implied.
Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.
How AICAR is characterized
Identity rests on the molecular formula and mass. Electrospray mass spectrometry (ESI-MS) measures the mass-to-charge ratio of the intact molecule; the average and monoisotopic masses are computed from the verified formula and cross-check the composition. The molecular formula and the scaffold noted above define the composition.
Frequently asked questions
What is AICAR?
Is AICAR a peptide?
What is the structure of AICAR?
What is the molecular formula of AICAR?
What are the key chemical identifiers for AICAR?
How is AICAR stored and reconstituted?
Does Lineará sell AICAR?
Is AICAR approved for human use?
Data, tools & related references
References
- PubChem — compound identity, structure & computed properties (CID 17513). PubChem →
- CAS Registry Number 2627-69-2.
- FDA Global Substance Registration System — UNII 53IEF47846.
Research professionals only
Reference data
This monograph is characterization reference data. Lineará does not sell, stock, or certify AICAR.