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Thymulin

Thymulin is a synthetic nonapeptide corresponding to thymulin (serum thymic factor), H-pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH, a classical zinc-associated thymic nonapeptide first characterized by Bach and Dardenne — distinct from the Khavinson short-peptide line and from the bovine-thymus extract Thymalin.

CAS 63958-90-7Mol. weight 858.86 g/molResearch Use Only · reference
2D structure of Thymulin (computed from the verified SMILES)
2D depiction computed with RDKit from the verified SMILES.

Identity & structure

pGlu
A
K
S
Q
G
G
S
N

Primary sequence · 9 residues · N-terminal pyroglutamate (pGlu); metal-free nonapeptide form.

Thymulin — identity and specification
Identity
CAS63958-90-7
PubChem CID3085284
FDA UNII9H198D04WL
Also known asThymulin peptide, Serum thymic factor, FTS, Facteur thymique serique, Nonathymulin, Zinc-thymulin
Research classRegenerative & Cytoprotective
Structure
Molecular formulaC33H54N12O15
InChIKeyLIFNDDBLJFPEAN-BPSSIEEOSA-N
SequencepGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
Length9 residues
Analytical
Average molecular weight858.86 g/mol
Monoisotopic mass858.3832 Da (computed)

A nonapeptide with an N-terminal pyroglutamate, H-pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH (serum thymic factor, FTS). The formula and mass here are for the metal-free nonapeptide, C33H54N12O15, the CAS-63958-90-7 entity; thymulin proper is the zinc-BOUND complex of this same nonapeptide, and the zinc is a bound cofactor — NOT part of the covalent formula (cf. the GHK-Cu precedent). Identity is reconciled against PubChem CID 3085284: the stereo-defined InChIKey LIFNDDBLJFPEAN-BPSSIEEOSA-N matches the deposited record exactly (seven stereocentres, none unassigned). It is a defined synthetic nonapeptide from a classical thymic lineage (Bach and Dardenne), NOT a Khavinson short peptide, and must be kept distinct from Thymalin — a bovine-thymus polypeptide extract with which registries frequently, and wrongly, conflate it; Thymalin is therefore excluded from the synonyms. A computed 3D conformer is held pending the chemist sign-off.

Reference context

Thymulin is a synthetic nonapeptide corresponding to thymulin (serum thymic factor), H-pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH, a classical zinc-associated thymic nonapeptide first characterized by Bach and Dardenne — distinct from the Khavinson short-peptide line and from the bovine-thymus extract Thymalin. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C33H54N12O15 and the values computed from it. No biological activity, mechanism, or use is described or implied.

Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.

How Thymulin is characterized

Identity rests on the molecular formula and mass. Electrospray mass spectrometry (ESI-MS) measures the mass-to-charge ratio of the intact molecule; the average and monoisotopic masses are computed from the verified formula and cross-check the composition. The residue sequence and the modifications noted above define the structure.

CompositionMolecular formula · 9-residue peptide
MassAverage & monoisotopic · ESI-MS
IdentityCAS · PubChem CID · UNII · InChIKey

Frequently asked questions

What is Thymulin?
Thymulin is a synthetic nonapeptide corresponding to thymulin (serum thymic factor), H-pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH, a classical zinc-associated thymic nonapeptide first characterized by Bach and Dardenne — distinct from the Khavinson short-peptide line and from the bovine-thymus extract Thymalin. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C33H54N12O15 and the values computed from it. No biological activity, mechanism, or use is described or implied.
What is the amino-acid sequence of Thymulin?
Thymulin has the sequence pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn. A nonapeptide with an N-terminal pyroglutamate, H-pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH (serum thymic factor, FTS). The formula and mass here are for the metal-free nonapeptide, C33H54N12O15, the CAS-63958-90-7 entity; thymulin proper is the zinc-BOUND complex of this same nonapeptide, and the zinc is a bound cofactor — NOT part of the covalent formula (cf. the GHK-Cu precedent). Identity is reconciled against PubChem CID 3085284: the stereo-defined InChIKey LIFNDDBLJFPEAN-BPSSIEEOSA-N matches the deposited record exactly (seven stereocentres, none unassigned). It is a defined synthetic nonapeptide from a classical thymic lineage (Bach and Dardenne), NOT a Khavinson short peptide, and must be kept distinct from Thymalin — a bovine-thymus polypeptide extract with which registries frequently, and wrongly, conflate it; Thymalin is therefore excluded from the synonyms. A computed 3D conformer is held pending the chemist sign-off.
What is the molecular formula of Thymulin?
Thymulin has the molecular formula C33H54N12O15, giving an average molecular weight of 858.86 g/mol and a computed monoisotopic mass of 858.3832 Da.
What are the key chemical identifiers for Thymulin?
The CAS Registry Number for Thymulin is 63958-90-7. Its PubChem CID is 3085284, its FDA UNII is 9H198D04WL, and its InChIKey is LIFNDDBLJFPEAN-BPSSIEEOSA-N.
Is Thymulin a peptide?
Yes. Thymulin is a peptide — a chain of amino-acid residues joined by peptide bonds, 9 residues in length. Its identity is defined by that sequence and its molecular mass.
How is Thymulin stored and reconstituted?
As a research material, Thymulin is typically handled as a lyophilized (freeze-dried) powder. It is kept desiccated and cold — commonly 2–8 °C for short periods and −20 °C for longer storage — and reconstituted in sterile or bacteriostatic water. This is storage and handling information only, not a use protocol.
Does Lineará sell Thymulin?
No. Thymulin is listed here only as an analytical reference entity. It is not part of the Lineará formulary, has no price or certificate of analysis, and is not offered for sale.
Is Thymulin approved for human use?
No. Thymulin is presented strictly as characterization reference data. It is not a drug, is not approved for any human or veterinary use, and must not be administered to humans or animals.

Data, tools & related references

References

  1. PubChem — compound identity, structure & computed properties (CID 3085284). PubChem →
  2. CAS Registry Number 63958-90-7.
  3. FDA Global Substance Registration System — UNII 9H198D04WL.

Research professionals only

Reference data

This monograph is characterization reference data. Lineará does not sell, stock, or certify Thymulin.

áFor Research Use Only · Not for human or veterinary use · Not for diagnostic or therapeutic use