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Regenerative & CytoprotectiveOpen access · public

SS-31

SS-31 is a synthetic mitochondria-targeted tetrapeptide, D-Arg-Dmt-Lys-Phe, with the molecular formula C32H49N9O5 and a molecular weight of 639.80 g/mol.

CAS 736992-21-5Mol. weight 639.80 g/molResearch Use Only
2D structure of SS-31 (PubChem CID 11764719)
2D structure via PubChem (CID 11764719). Public domain.
Computed 3D conformation (illustrative) · from the verified structure.

Identity & structure

Verified identifiers, sequence, and analytical properties — every value machine-readable and independently sourceable against PubChem.

D-Arg
Dmt
K
F
–NH₂

Primary sequence · 4 residues · C-terminal amide.

SS-31 — identity and specification
Identity
CAS736992-21-5
PubChem CID11764719
FDA UNII87GWG91S09
Also known asSS 31, SS-31 peptide, Elamipretide, MTP-131, Szeto-Schiller peptide
Research classRegenerative & Cytoprotective
Structure
Molecular formulaC32H49N9O5
InChIKeySFVLTCAESLKEHH-WKAQUBQDSA-N
SequenceD-Arg-Dmt-Lys-Phe
Length4 residues
Analytical
Average molecular weight639.80 g/mol
Monoisotopic mass639.3857 Da
FormLyophilized powder
SolubilityWater-soluble
Storage2–8 °C, desiccated

Research context

SS-31 is a synthetic mitochondria-targeted tetrapeptide, D-Arg-Dmt-Lys-Phe, with the molecular formula C32H49N9O5 and a molecular weight of 639.80 g/mol. It is studied in cytoprotection and mitochondrial research and is supplied as a characterized reference material, with identity confirmed by electrospray mass spectrometry and purity measured by reversed-phase HPLC.

Supplied solely as a characterized research material. No representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.

How SS-31 is identified

Identity and purity are measured, not asserted. Electrospray mass spectrometry (ESI-MS) determines the mass-to-charge ratio of the intact molecule — an observed value matching the expected series above confirms the molecular formula. Reversed-phase HPLC separates the sample over time, and purity is read as arithmetic: the target peak’s area as a share of total peak area.

IdentityESI-MS · observed vs expected m/z
PurityRP-HPLC · peak area %
CompositionMolecular formula · residue count

Handling & stability

Physical form, storage, and solubility as supplied. Handling guidance only — no use protocols.

Physical formLyophilized powder
Storage2–8 °C, desiccated
SolubilityWater-soluble
Length4 residues

Related compounds

Other compounds in this research class.

Frequently asked questions

What is SS-31?
SS-31 is a synthetic mitochondria-targeted tetrapeptide, D-Arg-Dmt-Lys-Phe, with the molecular formula C32H49N9O5 and a molecular weight of 639.80 g/mol. It is studied in cytoprotection and mitochondrial research and is supplied as a characterized reference material, with identity confirmed by electrospray mass spectrometry and purity measured by reversed-phase HPLC.
What is the molecular formula of SS-31?
SS-31 has the molecular formula C32H49N9O5, giving a molecular weight of 639.80 g/mol. Its monoisotopic mass is 639.3857 Da.
What is the CAS number of SS-31?
The CAS Registry Number for SS-31 is 736992-21-5. Its InChIKey is SFVLTCAESLKEHH-WKAQUBQDSA-N.
How is the identity of SS-31 confirmed?
Identity is confirmed by electrospray mass spectrometry. The observed mass-to-charge ratio is compared against the expected series — for SS-31, [M+H]⁺ is expected at m/z 640.39. Purity is measured separately by reversed-phase HPLC as the target peak’s share of total peak area.
How should SS-31 be stored?
SS-31 is supplied as lyophilized powder and should be stored at 2–8 °C, desiccated. It is water-soluble.
Is SS-31 a peptide?
Yes. SS-31 is a peptide — a chain of amino-acid residues joined by peptide bonds, 4 residues in length. Its identity is defined by that sequence and its molecular mass.
Is SS-31 approved for human use?
No. SS-31 is supplied strictly for laboratory research use only. It is not a drug, is not approved by the FDA for any human or veterinary use, and must not be administered to humans or animals.

Data, tools & certificates

References

  1. PubChem — compound identity, structure & computed properties (CID 11764719). PubChem →
  2. CAS Registry Number 736992-21-5.
  3. FDA Global Substance Registration System — UNII 87GWG91S09.

Research professionals only

SS-31 — from the record to the bench

The monograph and every lot certificate stay public. Pricing and ordering open for verified research professionals.

áFor Research Use Only · Not for human or veterinary use · Not for diagnostic or therapeutic use