ACE-031
ACE-031, also known by the International Nonproprietary Name ramatercept, is a recombinant fusion protein listed as a reference material.
Identity & structure
| Identity | |
|---|---|
| Type | Protein |
| Also known as | Ramatercept, ActRIIB-Fc, ActRIIB-IgG1 Fc fusion, ACVR2B-Fc, Soluble activin receptor type IIB, ACE031, ACE 031 |
| CAS | 1169766-01-1 |
| PubChem CID | Not assigned — a protein of this size receives no small-molecule PubChem CID |
| UniProt | Q13705 — parent receptor - human ACVR2B (ActRIIB); ACE-031 uses its extracellular domain |
| Research class | Regenerative & Cytoprotective |
| Structure | |
| Length | Homodimer of ActRIIB extracellular-domain–human IgG1 Fc monomers |
| Molecular formula | Not applicable — glycoprotein; mass heterogeneous |
| InChIKey | Not assigned — proteins are outside InChI’s practical domain |
| PDB (proxy) | 1S4Y, 1NYS |
| Analytical | |
| Monoisotopic mass | Not applicable — glycoprotein; mass heterogeneous |
Mass basis (glycoprotein — no single exact mass)
- Disulfide-linked homodimer, polypeptide basis (approx.)~76 kDa (about 38 kDa per monomer)
- Glycosylated protein (SDS-PAGE apparent)higher and heterogeneous
ACE-031 is a glycosylated Fc-fusion homodimer, not a single fully-specified covalent molecule: like Follistatin-344 in this reference set, its glycans are heterogeneous, so no single molecular formula, exact mass, monoisotopic mass, or InChIKey applies and none is computed. Identity is carried by the construct (ActRIIB extracellular domain fused to a human IgG1 Fc), the parent-receptor UniProt entry Q13705, and representative ActRIIB extracellular-domain structures in the Protein Data Bank (1S4Y, 1NYS), shown as labelled proxies rather than structures of ACE-031 itself. The CAS Registry Number 1169766-01-1 and UNII 42HQC6QLEK correspond to ramatercept; a different registry number circulated by some vendors denotes a distinct, much smaller molecule and is not this entity. ACE-031 is kept distinct from sotatercept (ACE-011, activin receptor type IIA), luspatercept (ACE-536) and bimagrumab.
Reference context
ACE-031, also known by the International Nonproprietary Name ramatercept, is a recombinant fusion protein listed as a reference material. It is built from two defined parts: the extracellular (ligand-binding) domain of human activin receptor type IIB (ActRIIB, gene ACVR2B, UniProt Q13705) fused to the Fc region of human immunoglobulin G1 (IgG1). The IgG1 Fc drives assembly into a disulfide-linked homodimer, giving the molecule its antibody-like architecture - the reason it is often written ActRIIB-Fc. According to peer-reviewed literature indexed in PubMed, ACE-031 was described by researchers at Acceleron Pharma as a soluble form of activin receptor type IIB (Attie et al., Muscle & Nerve, 2013; Cadena et al., J Appl Physiol, 2010) - a statement of molecular identity only. Because it is a glycosylated Fc-fusion, its mass is heterogeneous and no single molecular formula or exact mass applies; the disulfide-linked homodimer is on the order of 76 kDa on a polypeptide basis (about 38 kDa per monomer), with the glycosylated protein running higher and heterogeneously. Lineará lists ACE-031 as a characterization-only reference entity, distinct from the related soluble activin type IIA fusion sotatercept (ACE-011). For Research Use Only - not for human or veterinary use.
Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.
How ACE-031 is characterized
For a folded protein, identity rests on the amino-acid sequence and its cross-references rather than a small-molecule structure. The sequence above is the anchor identifier; the UniProt accession and the representative Protein Data Bank entries locate the fold. Because the native protein is glycosylated, its mass is heterogeneous: it is stated as a labeled basis (calculated polypeptide mass and apparent mass by SDS-PAGE), not a single number, and no single molecular formula or monoisotopic mass applies.
Frequently asked questions
What is ACE-031?
Is ACE-031 a peptide or a protein?
What is the molecular weight and formula of ACE-031?
What receptor is ACE-031 based on?
Does ACE-031 have a PubChem CID or InChIKey?
How is ACE-031 different from sotatercept (ACE-011)?
How is ACE-031 stored and reconstituted?
Does Lineará sell ACE-031?
Is ACE-031 approved for human use?
Data, tools & related references
References
Research professionals only
Reference data
This monograph is characterization reference data. Lineará does not sell, stock, or certify ACE-031.