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VIP (Vasoactive Intestinal Peptide)

VIP (Vasoactive Intestinal Peptide) is a synthetic 28-residue neuropeptide, H-His-Ser-Asp-...-Ile-Leu-Asn (HSDAVFTDNYTRLRKQMAVKKYLNSILN), first isolated from hog small intestine in 1970; the free-acid form (PubChem CID 53314964) is the reference record here, with the endogenous C-terminally amidated form noted alongside.

CAS 37221-79-7Mol. weight 3326.83 g/molResearch Use Only · reference
2D structure of VIP (Vasoactive Intestinal Peptide) (PubChem CID 53314964)
2D structure via PubChem (CID 53314964). Public domain.
Computed 3D conformation (illustrative) · from the verified structure.

Identity & structure

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Primary sequence · 28 residues · 28-residue neuropeptide (HSDAVFTDNYTRLRKQMAVKKYLNSILN); the free-acid form is shown here (PubChem CID 53314964). Endogenous VIP is C-terminally amidated (Asn-NH2), a distinct form with formula C147H238N44O42S..

VIP (Vasoactive Intestinal Peptide) — identity and specification
Identity
CAS37221-79-7
PubChem CID53314964
Also known asVasoactive intestinal polypeptide, VIP, VIP (1-28), VIP peptide
Research classSignaling & Neuroactive
Structure
Molecular formulaC147H237N43O43S
SequenceHSDAVFTDNYTRLRKQMAVKKYLNSILN
Length28 residues
Analytical
Average molecular weight3326.83 g/mol
Monoisotopic mass3324.7401 Da (computed)

A 28-residue neuropeptide, H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn (single-letter HSDAVFTDNYTRLRKQMAVKKYLNSILN), first isolated from hog small intestine by Said and Mutt in 1970; the human, mouse and rat sequences are identical. The identifiers here are for the FREE-ACID form deposited as PubChem CID 53314964 (formula C147H237N43O43S). Endogenous VIP is C-terminally amidated (Asn-NH2), which gives the distinct formula C147H238N44O42S — so the molecular formula and mass depend on which terminus is specified, a distinction recorded explicitly rather than elided. A single small-molecule InChIKey is omitted: VIP is represented by its verified sequence and PubChem CID, and the two termini would resolve to different keys.

Reference context

VIP (Vasoactive Intestinal Peptide) is a synthetic 28-residue neuropeptide, H-His-Ser-Asp-...-Ile-Leu-Asn (HSDAVFTDNYTRLRKQMAVKKYLNSILN), first isolated from hog small intestine in 1970; the free-acid form (PubChem CID 53314964) is the reference record here, with the endogenous C-terminally amidated form noted alongside. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C147H237N43O43S and the values computed from it. No biological activity, mechanism, or use is described or implied.

Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.

How VIP (Vasoactive Intestinal Peptide) is characterized

Identity rests on the molecular formula and mass. Electrospray mass spectrometry (ESI-MS) measures the mass-to-charge ratio of the intact molecule; the average and monoisotopic masses are computed from the verified formula and cross-check the composition. The residue sequence and the modifications noted above define the structure.

CompositionMolecular formula · 28-residue peptide
MassAverage & monoisotopic · ESI-MS
IdentityCAS · PubChem CID

Frequently asked questions

What is VIP (Vasoactive Intestinal Peptide)?
VIP (Vasoactive Intestinal Peptide) is a synthetic 28-residue neuropeptide, H-His-Ser-Asp-...-Ile-Leu-Asn (HSDAVFTDNYTRLRKQMAVKKYLNSILN), first isolated from hog small intestine in 1970; the free-acid form (PubChem CID 53314964) is the reference record here, with the endogenous C-terminally amidated form noted alongside. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C147H237N43O43S and the values computed from it. No biological activity, mechanism, or use is described or implied.
What is the amino-acid sequence of VIP (Vasoactive Intestinal Peptide)?
VIP (Vasoactive Intestinal Peptide) has the sequence HSDAVFTDNYTRLRKQMAVKKYLNSILN. A 28-residue neuropeptide, H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn (single-letter HSDAVFTDNYTRLRKQMAVKKYLNSILN), first isolated from hog small intestine by Said and Mutt in 1970; the human, mouse and rat sequences are identical. The identifiers here are for the FREE-ACID form deposited as PubChem CID 53314964 (formula C147H237N43O43S). Endogenous VIP is C-terminally amidated (Asn-NH2), which gives the distinct formula C147H238N44O42S — so the molecular formula and mass depend on which terminus is specified, a distinction recorded explicitly rather than elided. A single small-molecule InChIKey is omitted: VIP is represented by its verified sequence and PubChem CID, and the two termini would resolve to different keys.
What is the molecular formula of VIP (Vasoactive Intestinal Peptide)?
VIP (Vasoactive Intestinal Peptide) has the molecular formula C147H237N43O43S, giving an average molecular weight of 3326.83 g/mol and a computed monoisotopic mass of 3324.7401 Da.
What are the key chemical identifiers for VIP (Vasoactive Intestinal Peptide)?
The CAS Registry Number for VIP (Vasoactive Intestinal Peptide) is 37221-79-7. Its PubChem CID is 53314964.
Is VIP (Vasoactive Intestinal Peptide) a peptide?
Yes. VIP (Vasoactive Intestinal Peptide) is a peptide — a chain of amino-acid residues joined by peptide bonds, 28 residues in length. Its identity is defined by that sequence and its molecular mass.
How is VIP (Vasoactive Intestinal Peptide) stored and reconstituted?
As a research material, VIP (Vasoactive Intestinal Peptide) is typically handled as a lyophilized (freeze-dried) powder. It is kept desiccated and cold — commonly 2–8 °C for short periods and −20 °C for longer storage — and reconstituted in sterile or bacteriostatic water. This is storage and handling information only, not a use protocol.
Does Lineará sell VIP (Vasoactive Intestinal Peptide)?
No. VIP (Vasoactive Intestinal Peptide) is listed here only as an analytical reference entity. It is not part of the Lineará formulary, has no price or certificate of analysis, and is not offered for sale.
Is VIP (Vasoactive Intestinal Peptide) approved for human use?
No. VIP (Vasoactive Intestinal Peptide) is presented strictly as characterization reference data. It is not a drug, is not approved for any human or veterinary use, and must not be administered to humans or animals.

Data, tools & related references

References

  1. PubChem — compound identity, structure & computed properties (CID 53314964). PubChem →
  2. CAS Registry Number 37221-79-7.

Research professionals only

Reference data

This monograph is characterization reference data. Lineará does not sell, stock, or certify VIP (Vasoactive Intestinal Peptide).

áFor Research Use Only · Not for human or veterinary use · Not for diagnostic or therapeutic use