VIP (Vasoactive Intestinal Peptide)
VIP (Vasoactive Intestinal Peptide) is a synthetic 28-residue neuropeptide, H-His-Ser-Asp-...-Ile-Leu-Asn (HSDAVFTDNYTRLRKQMAVKKYLNSILN), first isolated from hog small intestine in 1970; the free-acid form (PubChem CID 53314964) is the reference record here, with the endogenous C-terminally amidated form noted alongside.

Identity & structure
Primary sequence · 28 residues · 28-residue neuropeptide (HSDAVFTDNYTRLRKQMAVKKYLNSILN); the free-acid form is shown here (PubChem CID 53314964). Endogenous VIP is C-terminally amidated (Asn-NH2), a distinct form with formula C147H238N44O42S..
| Identity | |
|---|---|
| CAS | 37221-79-7 |
| PubChem CID | 53314964 |
| Also known as | Vasoactive intestinal polypeptide, VIP, VIP (1-28), VIP peptide |
| Research class | Signaling & Neuroactive |
| Structure | |
| Molecular formula | C147H237N43O43S |
| Sequence | HSDAVFTDNYTRLRKQMAVKKYLNSILN |
| Length | 28 residues |
| Analytical | |
| Average molecular weight | 3326.83 g/mol |
| Monoisotopic mass | 3324.7401 Da (computed) |
A 28-residue neuropeptide, H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn (single-letter HSDAVFTDNYTRLRKQMAVKKYLNSILN), first isolated from hog small intestine by Said and Mutt in 1970; the human, mouse and rat sequences are identical. The identifiers here are for the FREE-ACID form deposited as PubChem CID 53314964 (formula C147H237N43O43S). Endogenous VIP is C-terminally amidated (Asn-NH2), which gives the distinct formula C147H238N44O42S — so the molecular formula and mass depend on which terminus is specified, a distinction recorded explicitly rather than elided. A single small-molecule InChIKey is omitted: VIP is represented by its verified sequence and PubChem CID, and the two termini would resolve to different keys.
Reference context
VIP (Vasoactive Intestinal Peptide) is a synthetic 28-residue neuropeptide, H-His-Ser-Asp-...-Ile-Leu-Asn (HSDAVFTDNYTRLRKQMAVKKYLNSILN), first isolated from hog small intestine in 1970; the free-acid form (PubChem CID 53314964) is the reference record here, with the endogenous C-terminally amidated form noted alongside. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C147H237N43O43S and the values computed from it. No biological activity, mechanism, or use is described or implied.
Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.
How VIP (Vasoactive Intestinal Peptide) is characterized
Identity rests on the molecular formula and mass. Electrospray mass spectrometry (ESI-MS) measures the mass-to-charge ratio of the intact molecule; the average and monoisotopic masses are computed from the verified formula and cross-check the composition. The residue sequence and the modifications noted above define the structure.
Frequently asked questions
What is VIP (Vasoactive Intestinal Peptide)?
What is the amino-acid sequence of VIP (Vasoactive Intestinal Peptide)?
What is the molecular formula of VIP (Vasoactive Intestinal Peptide)?
What are the key chemical identifiers for VIP (Vasoactive Intestinal Peptide)?
Is VIP (Vasoactive Intestinal Peptide) a peptide?
How is VIP (Vasoactive Intestinal Peptide) stored and reconstituted?
Does Lineará sell VIP (Vasoactive Intestinal Peptide)?
Is VIP (Vasoactive Intestinal Peptide) approved for human use?
Data, tools & related references
References
- PubChem — compound identity, structure & computed properties (CID 53314964). PubChem →
- CAS Registry Number 37221-79-7.
Research professionals only
Reference data
This monograph is characterization reference data. Lineará does not sell, stock, or certify VIP (Vasoactive Intestinal Peptide).