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Signaling & NeuroactiveOpen access · public

SNAP-8

SNAP-8 is a synthetic, N-acetylated and C-terminally amidated octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRAD-NH2), that extends the acetyl-hexapeptide (argireline) motif by two residues.

CAS 868844-74-0Mol. weight 1075.17 g/molResearch Use Only · reference
2D structure of SNAP-8 (computed from the verified SMILES)
2D depiction computed with RDKit from the verified SMILES.
Computed 3D conformation (illustrative) · from the verified structure.

Identity & structure

Ac–
E
E
M
Q
R
R
A
D
–NH₂

Primary sequence · 8 residues · N-terminal Acetyl · C-terminal amide · Octapeptide amide (Ac-EEMQRRAD-NH2): eight L-amino acids, N-acetylated and C-terminally amidated. Extends the acetyl-hexapeptide (argireline) motif Ac-EEMQRR- by the two residues Ala-Asp..

SNAP-8 — identity and specification
Identity
CAS868844-74-0
Also known asAcetyl Octapeptide-3, Acetyl Octapeptide-1, Acetyl Glutamyl Heptapeptide-1, Octapeptide-3, SNAP 8, SNAP-8 peptide
Research classSignaling & Neuroactive
Structure
Molecular formulaC41H70N16O16S
SequenceAc-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Length8 residues
Analytical
Average molecular weight1075.17 g/mol
Monoisotopic mass1074.4876 Da (computed)

SNAP-8 has the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (single-letter Ac-EEMQRRAD-NH2): eight L-amino acids capped with an N-terminal acetyl group and a C-terminal primary amide. Its lone methionine contributes the single sulfur atom, and the sequence computes exactly to the molecular formula C41H70N16O16S (average mass 1075.17 g/mol). No PubChem CID is published here: the record catalogued as "Acetyl octapeptide-3" (CID 71587832) stores a different formula, C42H72N16O15S, which does not reconcile with this sequence, so it is not shipped as a verified identifier and is flagged for chemist review as a likely record error. No InChIKey or FDA UNII is asserted for the same reason — neither could be machine-verified against a reconciled record.

Reference context

SNAP-8 is a synthetic, N-acetylated and C-terminally amidated octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRAD-NH2), that extends the acetyl-hexapeptide (argireline) motif by two residues. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C41H70N16O16S and the values computed from it. No biological activity, mechanism, or use is described or implied.

Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.

How SNAP-8 is characterized

Identity rests on the molecular formula and mass. Electrospray mass spectrometry (ESI-MS) measures the mass-to-charge ratio of the intact molecule; the average and monoisotopic masses are computed from the verified formula and cross-check the composition. The residue sequence and the modifications noted above define the structure.

CompositionMolecular formula · 8-residue peptide
MassAverage & monoisotopic · ESI-MS
IdentityCAS

Frequently asked questions

What is SNAP-8?
SNAP-8 is a synthetic, N-acetylated and C-terminally amidated octapeptide, Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (Ac-EEMQRRAD-NH2), that extends the acetyl-hexapeptide (argireline) motif by two residues. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C41H70N16O16S and the values computed from it. No biological activity, mechanism, or use is described or implied.
What is the amino-acid sequence of SNAP-8?
SNAP-8 has the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2. SNAP-8 has the sequence Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2 (single-letter Ac-EEMQRRAD-NH2): eight L-amino acids capped with an N-terminal acetyl group and a C-terminal primary amide. Its lone methionine contributes the single sulfur atom, and the sequence computes exactly to the molecular formula C41H70N16O16S (average mass 1075.17 g/mol). No PubChem CID is published here: the record catalogued as "Acetyl octapeptide-3" (CID 71587832) stores a different formula, C42H72N16O15S, which does not reconcile with this sequence, so it is not shipped as a verified identifier and is flagged for chemist review as a likely record error. No InChIKey or FDA UNII is asserted for the same reason — neither could be machine-verified against a reconciled record.
What is the molecular formula of SNAP-8?
SNAP-8 has the molecular formula C41H70N16O16S, giving an average molecular weight of 1075.17 g/mol and a computed monoisotopic mass of 1074.4876 Da.
What are the key chemical identifiers for SNAP-8?
The CAS Registry Number for SNAP-8 is 868844-74-0.
Is SNAP-8 a peptide?
Yes. SNAP-8 is a peptide — a chain of amino-acid residues joined by peptide bonds, 8 residues in length. Its identity is defined by that sequence and its molecular mass.
How is SNAP-8 stored and reconstituted?
As a research material, SNAP-8 is typically handled as a lyophilized (freeze-dried) powder. It is kept desiccated and cold — commonly 2–8 °C for short periods and −20 °C for longer storage — and reconstituted in sterile or bacteriostatic water. This is storage and handling information only, not a use protocol.
Does Lineará sell SNAP-8?
No. SNAP-8 is listed here only as an analytical reference entity. It is not part of the Lineará formulary, has no price or certificate of analysis, and is not offered for sale.
Is SNAP-8 approved for human use?
No. SNAP-8 is presented strictly as characterization reference data. It is not a drug, is not approved for any human or veterinary use, and must not be administered to humans or animals.

Data, tools & related references

References

  1. CAS Registry Number 868844-74-0.

Research professionals only

Reference data

This monograph is characterization reference data. Lineará does not sell, stock, or certify SNAP-8.

áFor Research Use Only · Not for human or veterinary use · Not for diagnostic or therapeutic use