Humanin

Humanin is a 24-residue mitochondrial-derived peptide (a mitokine) encoded within the mitochondrial 16S rRNA gene MT-RNR2 — the founding member of the mitochondrial-derived peptide (MDP) family — with the sequence MAPRGFSCLLLLTSEIDLPVKRRA. It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C119H204N34O32S2 and the values computed from it. "mitochondrial-derived peptide (MDP)" is a structural-family descriptor; no biological activity, mechanism, or use is described or implied.

Humanin has the sequence MAPRGFSCLLLLTSEIDLPVKRRA. Humanin is a 24-residue peptide encoded within the mitochondrial 16S ribosomal RNA gene MT-RNR2 — the founding member of the mitochondrial-derived peptide (MDP) family. Its single-letter sequence MAPRGFSCLLLLTSEIDLPVKRRA carries one methionine (the N-terminal residue) and one cysteine (position 8), which together supply the two sulfur atoms in the molecular formula C119H204N34O32S2; the C-terminus is the free acid. Identity is reconciled against PubChem CID 16131438: molecular formula, isomeric SMILES, and the stereo-defined InChIKey DPEUWKZJZIPZKE-OFANTOPUSA-N all match a peptide assembled independently from the sequence (twenty-five stereocentres, none unassigned). The more potent analog HNG (S14G-Humanin, a serine-14-to-glycine substitution) and the longer rat ortholog Rattin are distinct entities, recorded here only as search synonyms.

Humanin has the molecular formula C119H204N34O32S2, giving an average molecular weight of 2687.27 g/mol and a computed monoisotopic mass of 2685.4822 Da.

The CAS Registry Number for Humanin is 330936-69-1. Its PubChem CID is 16131438, its FDA UNII is H975EUX36G, and its InChIKey is DPEUWKZJZIPZKE-OFANTOPUSA-N.

Yes. Humanin is a peptide — a chain of amino-acid residues joined by peptide bonds, 24 residues in length. Its identity is defined by that sequence and its molecular mass.

As a research material, Humanin is typically handled as a lyophilized (freeze-dried) powder. It is kept desiccated and cold — commonly 2–8 °C for short periods and −20 °C for longer storage — and reconstituted in sterile or bacteriostatic water. This is storage and handling information only, not a use protocol.

No. Humanin is listed here only as an analytical reference entity. It is not part of the Lineará formulary, has no price or certificate of analysis, and is not offered for sale.

No. Humanin is presented strictly as characterization reference data. It is not a drug, is not approved for any human or veterinary use, and must not be administered to humans or animals.