Dihexa
Dihexa is a synthetic peptidomimetic derived from angiotensin IV, an L-tyrosyl-L-isoleucine core hexanoylated at the N-terminus and extended at the C-terminus by a 6-aminohexanoic-acid amide (N-hexanoyl-Tyr-Ile-6-aminohexanamide).
Identity & structure
Primary sequence · 3 residues · N-terminal hexanoyl · C-terminal amide · Peptidomimetic derived from angiotensin IV: an L-Tyr-L-Ile core, N-capped with a hexanoyl group and extended by a non-proteinogenic 6-aminohexanoic-acid residue (Ahx) that terminates in a primary amide. The hexanoyl cap and the C-terminal amide are modifications, not residues..
| Identity | |
|---|---|
| CAS | 1401708-83-5 |
| PubChem CID | 129010512 |
| FDA UNII | 9WYX65A5C2 |
| Also known as | PNB-0408, PNB0408, Dihexa peptide |
| Research class | Signaling & Neuroactive |
| Structure | |
| Molecular formula | C27H44N4O5 |
| InChIKey | XEUVNVNAVKZSPT-JTJYXVOQSA-N |
| Sequence | Hexanoyl-Tyr-Ile-6-aminohexanamide |
| Length | 3 residues |
| Analytical | |
| Average molecular weight | 504.66 g/mol |
| Monoisotopic mass | 504.3312 Da (computed) |
A peptidomimetic built on an L-tyrosyl-L-isoleucine core, N-capped with a hexanoyl (C6 fatty-acyl) group and C-extended by a 6-aminohexanoic-acid residue terminating in a primary amide, systematically named N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide. Its three stereocentres — the tyrosine alpha-carbon and the isoleucine alpha- and beta-carbons — are all defined and reproduce InChIKey XEUVNVNAVKZSPT-JTJYXVOQSA-N. Counting Tyr, Ile and the non-proteinogenic 6-aminohexanoic-acid unit gives three residues; the hexanoyl cap and the C-terminal amide are modifications, not residues.
Reference context
Dihexa is a synthetic peptidomimetic derived from angiotensin IV, an L-tyrosyl-L-isoleucine core hexanoylated at the N-terminus and extended at the C-terminus by a 6-aminohexanoic-acid amide (N-hexanoyl-Tyr-Ile-6-aminohexanamide). It is listed here strictly as an analytical reference entity — it is not sold, stocked, or certified by Lineará, and has no price or certificate of analysis. The data on this page is characterization only: molecular formula C27H44N4O5 and the values computed from it. No biological activity, mechanism, or use is described or implied.
Listed solely as a characterized analytical reference — no representation is made as to any biological effect. For Research Use Only — not for human or veterinary use.
How Dihexa is characterized
Identity rests on the molecular formula and mass. Electrospray mass spectrometry (ESI-MS) measures the mass-to-charge ratio of the intact molecule; the average and monoisotopic masses are computed from the verified formula and cross-check the composition. The residue sequence and the modifications noted above define the structure.
Frequently asked questions
What is Dihexa?
What is the amino-acid sequence of Dihexa?
What is the molecular formula of Dihexa?
What are the key chemical identifiers for Dihexa?
Is Dihexa a peptide?
How is Dihexa stored and reconstituted?
Does Lineará sell Dihexa?
Is Dihexa approved for human use?
Data, tools & related references
References
- PubChem — compound identity, structure & computed properties (CID 129010512). PubChem →
- CAS Registry Number 1401708-83-5.
- FDA Global Substance Registration System — UNII 9WYX65A5C2.
Research professionals only
Reference data
This monograph is characterization reference data. Lineará does not sell, stock, or certify Dihexa.